Men, cars, anacondas, bears, big alligators and crocodiles, tigers and wild dogs. That's what it's enemies are
That would be the....Floridians :}
Humans
Man and his automobiles. When I lived in Florida the only thing I ever heard about killing the panthers at the time was cars. In previous generations they were hunted by man until laws were passed against this. There are no natural predators of the Florida Panther other than man.
The florida panthers enemies are humans we ruin there habitat kill them for fur and meat we need to stop this!